Day 2 :
- Orthodontics & Prosthodontics | Periodontics, Gingivitis, Endodontics | Dental Treatment and Medicines| Dental Implant | Oral Cancer
Location: Renaissance polat istanbul hotel , Turkey
Chair
Hatem Alfakry
University of Helsinki, Finland
Session Introduction
Mehdi Shahabinejad
Mashhad University of Medical Sciences, Iran
Title: Evaluation of gene expression of CD208 (LAMP3) in oral squamous cell carcinoma and dysplasia of oral epithelium by real-time RT-PCR technique
Biography:
Mehdi Shahabinejad is currently working as a Professor at Department of oral and maxillofacial pathology, College of Dentistry, Mashhad University of Medical Sciences, Iran
Abstract:
Introduction & Objective: Oral squamous cell carcinoma is the most prevalent malignancy of the mouth which includes more than 90% of oral cancers. LAMP3 is a member of LAMP family and dendritic cell marker located on its membrane. Recent studies showed high expression of this gene in esophageal SCC, head and neck SCC and also cancer of breast, digestive tract and cervix. The objective of this study was to evaluate the expression of LAMP3 gene in oral squamous cell carcinoma and dysplastic oral epithelium by Real-time reverse transcription polymerase (RT-PCR) and also comparing of LAMP3 expression between grade I, II, III OSCC with each other and with dysplastic epithelium.
Method: In this study, 60 samples of squamous cell carcinoma and dysplastic epithelium of oral cavity obtained from the archive of oral and maxillofacial Pathology Department of Mashhad University of Medical Sciences together with their corresponding age and gender information. At the beginning total RNA from all the specimens obtained and gene expression evaluated by Real-time PCR.
Results: In this study 60 sample from 60 patients including 33 female (55%) 27 male (45%) with mean age of 57.7 year and extent of 23-84 years old were evaluated quantitatively for LAMP3 gene expression for grades I, II, III OSCC and dysplastic epithelium result showed that there have been significant difference between different grades of OSCC and dysplastic epithelium. The mean expression of LAMP3 between each grade of OSCC show that grade III had high expression in comparison with grade I, II and dysplastic epithelium and it was almost two times that of grade I and II and also mean expression was lowest in dysplastic epithelium comparing with the OSCC, but there have not been significant difference between grade I and II. The average expression of LAMP3 was higher in OSCC than dysplastic group (p<0.001).
Conclusion: According to our results, higher expression of LAMP3 from dysplastic epithelium to OSCC indicates the process of carcinogenesis in oral mucosa. In higher grades of OSCC with lower differentiation, LAMP3 expression is increasing, so that LAMP3 mRNA in OSCC grade III was higher than OSCC grade I and II.
Guhan Dergin
Marmara University, Turkey
Title: Surgical methods for the augmentation of horizontal or vertical alveolar bone deficiencies for implant rehabilitation
Biography:
Guhan Dergin was born in 1973 in Izmit, Turkey. He graduated from Marmara University Faculty of Dentistry in 1999. He completed his specialty of OMFS surgery in Marmara University Faculty of Dentistry obtained his PhD degree in 2006. In 2005, he was invited as a visiting doctor in the Oral and Maxillofacial Surgery Department of the University of North Carolina, USA, where he went on a scholarship. Dr. Guhan still continues his academic career as an associate professor in Marmara University Faculty of Dentistry. Assoc. has given invited lectures as guest speaker at national and international congresses. Also he is in the board of drectors of Association of Oral &Maxillofacial Surgery (ACBID). He has many articles in international and national scientific journals and chapters in books
Abstract:
Dental implants rehabilitations are the most prefered method of tooth replacement in modern dentistry. Vertical and horizontal bone deficiencies are the major obstacles of this treatment. Surgical principles of vertical and bone grafting, such as stabilization of grafts, space maintenance, and proper wound closure are fort coming points for success. But determining the most appropriate surgical method for the augmentation of horizontal or vertical insufficiency is the key stone of the treatment success.
Biography:
Etemad Wadie Al taweel graduate from Cairo University in 1996 with Bachelor of Dental Science(B. Dental. SC.) Working at Hamad Medical Corporation as clinical associate in endodontic and restorative specialty up to date in Qatar.
Abstract:
Occupational health is aimed to provide and maintain the highest degree of mental, physical and social welfare of workers in all different professions. Occupational stress one of the concerns of present-day public health services Stress in the workplace continues to be a highly pervasive problem, having direct and in -direct negative effects on individuals and productivity. Causes of occupational stress include environments, organizational climate, and a conflict arises from the job demands of the employees. Adverse health effects as examples of psychological disorders, cardiovascular disease, gastrointestinal disease and other adverse effect on human body Establishment of the National Institute for Occupational Safety and Health (NIOSH) and Occupational Safety and Health Administration (OSHA) research agency focused on the study of worker safety and health, and empowering employers and workers to create safe and healthy workplaces. A lot of studies and researches done by (NIOSH), (OSHA) to create guidelines on organizational change to prevent occupational stress is useful. Prevention Interventions to eliminate or reduce the occupational stress should be both at organizational and individual levels through brief explanation of primary, secondary and tertiary prevention.